Acute Lymphoblastic Leukemia (ALL)

What is acute lymphoblastic leukemia?

Acute lymphoblastic leukemia, or "ALL," is a type of blood cancer. ALL grows very fast and needs to be treated quickly.

Blood is made up of different types of cells. These cells are made in the center of bones, in a part called bone marrow.

When people have ALL, their bone marrow makes abnormal blood cells. These abnormal cells grow out of control, get into the blood, and travel around the body. Sometimes, they collect in certain parts of the body.

When bone marrow makes abnormal blood cells, it does not make the normal blood cells a person's body needs. This can cause symptoms.

What are the symptoms of ALL?

The most common symptoms include:

• Feeling very tired and weak

• Bleeding or bruising more easily than normal

• Getting sick from infections more easily than normal

Is there a test for ALL?

Yes. Your doctor or nurse will talk with you and do an exam. They will also do:

• Blood tests

• Bone marrow biopsy – A doctor removes a small sample of bone marrow using a needle. Then, the sample is examined under a microscope to see if ALL cells are present.

How is ALL treated?

Treatment for ALL is usually made up of 3 parts:

1. Induction of remission – It lasts about 4 weeks. During this part, people generally stay in the hospital and get chemotherapy. Chemotherapy is the medical term for medicines that kill cancer cells or stop them from growing.

   Depending on your specific type of ALL, you might also get other treatments:

   • Immune therapy – Works with your body's infection-fighting system to kill cancer cells.

   • Targeted therapy – Involves medicines that work only for cancers with certain characteristics.

   Most people are in "remission" after getting chemotherapy. This means that doctors do not see any more abnormal ALL cells in their blood or bone marrow. But even though doctors do not see any abnormal cells, there are still ALL cells in the body. To kill these cells and prevent the ALL from returning, people need more treatment.

2. Consolidation/intensification therapy – It lasts a few months. During this part, people generally have more chemotherapy. But it is given at a lower dose than before, and you might not need to stay in the hospital overnight.

3. Maintenance therapy – It might last 2 or more years. During this part, people get chemotherapy once a month. They also take other medicines (pills) on certain days of the month. Many people can return to their usual activities during this part.